abstract：:Death-associated protein kinase 1 (DAPK1, DAPk, DAPK) is known for its involvement in apoptosis and autophagy-associated cell death. Here, we identified an unexpected function of DAPK1 in suppressing necroptosis. DAPK1-deficiency renders macrophages and dendritic cells susceptible to necroptotic death. We also observe...

journal_title：Cell death & disease

authors： Wu YH,Chou TF,Young L,Hsieh FY,Pan HY,Mo ST,Brown SB,Chen RH,Kimchi A,Lai MZ

更新日期：2020-05-04 00:00:00

abstract：:Primary liver cancer (PLC) may be mainly classified as the following four types: hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC), hepatoblastoma (HB), and combined hepatocellular carcinoma and intrahepatic cholangiocarcinoma (cHCC-ICC). The majority of PLC develops in the background of tumor micr...

journal_title：Cell death & disease

authors： Wang G,Wang Q,Liang N,Xue H,Yang T,Chen X,Qiu Z,Zeng C,Sun T,Yuan W,Liu C,Chen Z,He X

更新日期：2020-05-04 00:00:00

abstract：:DNA damage regulated autophagy modulator 1 (DRAM1) is a stress-inducible regulator of autophagy and cell death. DRAM1 has been implicated in cancer, myocardial infarction, and infectious diseases, but the molecular and cellular functions of this transmembrane protein remain poorly understood. Previously, we have propo...

journal_title：Cell death & disease

authors： Zhang R,Varela M,Forn-Cuní G,Torraca V,van der Vaart M,Meijer AH

更新日期：2020-04-24 00:00:00

abstract：:The DEAD/DEAH box helicase 11 (DDX11) plays vital roles in regulating the initiation of DNA replication. However, its precise function and regulation in hepatocellular carcinoma (HCC) have never been reported yet. In the current study, we found that DDX11 was overexpressed in HCC tissues. High DDX11 expression was pos...

journal_title：Cell death & disease

authors： Yu Y,Zhao D,Li K,Cai Y,Xu P,Li R,Li J,Chen X,Chen P,Cui G

更新日期：2020-04-24 00:00:00

abstract：:Melanoma is a kind of tumor that originates from melanocytes and is characterized by chemoresistance and distant metastasis. Although the complete pathogenesis of melanoma remains unclear, increasing evidence suggests that circular RNAs (circRNAs) may be involved. In the present study, we identified a circular RNA, ci...

journal_title：Cell death & disease

authors： Qian P,Linbo L,Xiaomei Z,Hui P

更新日期：2020-04-23 00:00:00

abstract：:Neural stem cells are activated within neurogenic niches in response to brain injuries. This results in the production of neuroblasts, which unsuccessfully attempt to migrate toward the damaged tissue. Injuries constitute a gliogenic/non-neurogenic niche generated by the presence of anti-neurogenic signals, which impa...

journal_title：Cell death & disease

authors： Domínguez-García S,Geribaldi-Doldán N,Gómez-Oliva R,Ruiz FA,Carrascal L,Bolívar J,Verástegui C,Garcia-Alloza M,Macías-Sánchez AJ,Hernández-Galán R,Nunez-Abades P,Castro C

更新日期：2020-04-22 00:00:00

abstract：:The adaptation of mitochondrial homeostasis to ischemic injury is not fully understood. Here, we studied the role of dynamin-related protein 1 (Drp1) in this process. We found that mitochondrial morphology was altered in the early stage of ischemic injury while mitochondrial dysfunction occurred in the late stage of i...

journal_title：Cell death & disease

authors： Duan C,Kuang L,Xiang X,Zhang J,Zhu Y,Wu Y,Yan Q,Liu L,Li T

更新日期：2020-04-20 00:00:00

abstract：:Vascular endothelial growth factor receptor (VEGFR) and neuropilins (NRPs), a co-receptor of VEGF, play a key role in the formation and development of blood vessels and in tumour growth and metastasis. However, whether VEGFR1/2 and NRP1 are regulated by the same upstream mechanism is unclear, especially in gastric can...

journal_title：Cell death & disease

authors： Mei B,Chen J,Yang N,Peng Y

更新日期：2020-04-17 00:00:00

abstract：:Prostate cancer stem cells (PCSCs) play a critical role in prostate cancer progression and metastasis, which remains an obstacle for successful prostate cancer treatment. Tumor-associated macrophages (TAMs) are the most abundant immune cell population within the tumor microenvironment (TME). Systematic investigation o...

journal_title：Cell death & disease

authors： Huang R,Wang S,Wang N,Zheng Y,Zhou J,Yang B,Wang X,Zhang J,Guo L,Wang S,Chen Z,Wang Z,Xiang S

更新日期：2020-04-16 00:00:00

abstract：:This study aimed to evaluate treatment response, survival, safety profiles, and predictive factors to chimeric antigen receptor T cell (CAR-T) therapy in Chinese patients with relapsed or refractory B cell acute lymphoblast leukemia (R/R B-ALL). 39R/R B-ALL patients who underwent CAR-T therapy were included. Baseline ...

journal_title：Cell death & disease

authors： Li L,Liu J,Xu M,Yu H,Lv C,Cao F,Wang Z,Fu Y,Zhang M,Meng H,Zhang X,Kang L,Zhang Z,Li J,Feng J,Lian X,Yu L,Zhou J

更新日期：2020-03-30 00:00:00

abstract：:Hepatocytes undergo the metaplasia into ductal biliary epithelial cells (BECs) in response to chronic injury, and subsequently contribute to liver regeneration. The mechanism underlying hepatocyte-to-ductal metaplasia has not been explored until now. In mouse models of liver fibrosis, a florid BEC response was observe...

journal_title：Cell death & disease

authors： Xu T,Lu Z,Xiao Z,Liu F,Chen Y,Wang Z,Zhu S,Song Y

更新日期：2020-03-23 00:00:00

abstract：:The link between tendon stem/progenitor cells (TSPCs) senescence and tendon aging has been well recognized. However, the cellular and molecular mechanisms of TSPCs senescence are still not fully understood. In present study, we investigated the role of Aquaporin 1 (AQP1) in TSPCs senescence. We showed that AQP1 expres...

journal_title：Cell death & disease

authors： Chen M,Li Y,Xiao L,Dai G,Lu P,Wang Y,Rui Y

更新日期：2020-03-18 00:00:00

abstract：:Treatment options for necrotizing enterocolitis (NEC) remain inadequate. Here we examined if and how prolyl hydroxylase 2 (PHD2) silencing enhances the paracrine effects of bone-marrow-derived mesenchymal stem cells (BM-MSCs) on NEC. In this study, BM-MSCs were transduced with lentiviruses containing GFP (GFP-MSC) or ...

journal_title：Cell death & disease

authors： Chen H,Zhang H,Zheng Y,Min X,Luo Y,Zhou W,Ma F,Li J,Lu Q,Zhang C,Cai H,Sha W

更新日期：2020-03-16 00:00:00

abstract：:Providing a conducive microenvironment is critical to increase survival of transplanted stem cells in regenerative therapy. Hyperglycemia promotes stem cell death impairing cardiac regeneration in the diabetic heart. Understanding the molecular mechanisms of high glucose-induced stem cell death is important for improv...

journal_title：Cell death & disease

authors： Yadav SK,Kambis TN,Kar S,Park SY,Mishra PK

更新日期：2020-03-13 00:00:00

abstract：:The intrinsic apoptotic pathway is controlled by the BCL-2 family of proteins, which exhibit either a pro-death or pro-survival function. Gene knockout studies revealed that different pro-survival BCL-2 proteins are critical for the survival of distinct cell types, although overlapping functions amongst such proteins ...

journal_title：Cell death & disease

authors： Ke F,Lancaster GI,Grabow S,Murphy AJ,Strasser A

更新日期：2020-03-13 00:00:00

abstract：:The positive results of the apatinib phase III trial have cast new light on treatment for patients with advanced gastric cancer (GC). However, in terms of safety, apatinib toxicities may lead to a dose modification or treatment interruption. Therefore, proper intervention is urgently needed to help patients benefit fr...

journal_title：Cell death & disease

authors： Ma L,Wang Z,Xie M,Quan Y,Zhu W,Yang F,Zhao C,Fan Y,Fang N,Jiang H,Wang Q,Wang S,Zhou J,Chen X,Shu Y

更新日期：2020-03-05 00:00:00

abstract：:Metastasis is the leading cause of death for colorectal cancer (CRC). However, the protein transport process involved in CRC metastasis remains unclear. In this report, we use whole-exome sequencing and bioinformatics analysis to identify somatic mutations in CRC samples and found mutations of the protein transport ge...

journal_title：Cell death & disease

authors： Yang C,Chen N,Li X,Lu D,Hou Z,Li Y,Jin Y,Gu J,Yin Y

更新日期：2020-03-02 00:00:00

abstract：:Abdominal Aortic aneurysm (AAA) is associated with chronic inflammation, cells apoptosis, and impairment of autophagy. BP-1-102, a novel potent STAT3 inhibitor, has been recently reported to significantly block inflammation-related signaling pathways of JAK2/STAT3 and NF-κB, as well as regulate autophagy. However, its...

journal_title：Cell death & disease

authors： Wu QY,Cheng Z,Zhou YZ,Zhao Y,Li JM,Zhou XM,Peng HL,Zhang GS,Liao XB,Fu XM

更新日期：2020-02-18 00:00:00

abstract：:Circular RNAs (circRNAs) have been shown to play critical roles in cancer biology, but their functions in nonalcoholic steatohepatitis (NASH) remain unexplored. Full length of circRNA_002581 was amplified and sequenced, followed by RNA immunoprecipitation, RNA-Fluorescence in Situ Hybridization and dual luciferase rep...

journal_title：Cell death & disease

authors： Jin X,Gao J,Zheng R,Yu M,Ren Y,Yan T,Huang Y,Li Y

更新日期：2020-02-13 00:00:00

abstract：:Despite the introduction of novel targeted therapies, chemotherapy still remains the primary treatment for metastatic melanoma in poorly funded healthcare environments or in case of disease relapse, with no reliable molecular markers for progression-free survival (PFS) available. As chemotherapy primarily eliminates c...

journal_title：Cell death & disease

authors： Guttà C,Rahman A,Aura C,Dynoodt P,Charles EM,Hirschenhahn E,Joseph J,Wouters J,de Chaumont C,Rafferty M,Warren M,van den Oord JJ,Gallagher WM,Rehm M

更新日期：2020-02-13 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Cell death & disease

authors： Moon H-,Cao Y,Yang J,Lee JH,Choi HS,Jin Y

更新日期：2020-02-12 00:00:00

abstract：:p53-mutated tumors often exhibit increased resistance to standard chemotherapy and enhanced metastatic potential. Here we demonstrate that inhibition of dihydroorotate dehydrogenase (DHODH), a key enzyme of the de novo pyrimidine synthesis pathway, effectively decreases proliferation of cancer cells via induction of r...

journal_title：Cell death & disease

authors： Hubackova S,Davidova E,Boukalova S,Kovarova J,Bajzikova M,Coelho A,Terp MG,Ditzel HJ,Rohlena J,Neuzil J

更新日期：2020-02-07 00:00:00

abstract：:Caveolin-1 (CAV1) is a crucial regulator of lipid accumulation and metabolism. Previous studies have shown that global Cav1 deficiency affects lipid metabolism and hepatic steatosis. We aimed to analyze the consequences of hepatocyte-specific Cav1 knockout under healthy conditions and upon non-alcoholic fatty liver di...

journal_title：Cell death & disease

authors： Han M,Piorońska W,Wang S,Nwosu ZC,Sticht C,Wang S,Gao Y,Ebert MP,Dooley S,Meyer C

更新日期：2020-02-06 00:00:00

abstract：:Adult T-cell leukemia/lymphoma (ATLL) is a malignancy of mature T cells associated with chronic infection by human T-cell lymphotropic virus type-1 (HTLV-1). ATLL patients with aggressive subtypes have dismal outcomes. We demonstrate that ATLL cells co-opt an early checkpoint within the tumor necrosis factor receptor ...

journal_title：Cell death & disease

authors： Xu X,Kalac M,Markson M,Chan M,Brody JD,Bhagat G,Ang RL,Legarda D,Justus SJ,Liu F,Li Q,Xiong H,Ting AT

更新日期：2020-02-05 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the major type of primary liver cancer. Genomic studies have revealed that HCC is a heterogeneous disease with multiple subtypes. BRG1, encoded by the SMARCA4 gene, is a key component of SWI/SNF chromatin-remodeling complexes. Based on TCGA studies, somatic mutations of SMARCA4 occur ...

journal_title：Cell death & disease

authors： Wang P,Song X,Cao D,Cui K,Wang J,Utpatel K,Shang R,Wang H,Che L,Evert M,Zhao K,Calvisi DF,Chen X

更新日期：2020-02-04 00:00:00

abstract：:Erythropoietin (EPO) is an evolutionarily conserved hormone well documented for its erythropoietic role via binding the homodimeric EPO receptor (EPOR)2. In past decades, evidence has proved that EPO acts far beyond erythropoiesis. By binding the tissue-protective receptor (TPR), EPO suppresses proinflammatory cytokin...

journal_title：Cell death & disease

authors： Peng B,Kong G,Yang C,Ming Y

更新日期：2020-02-03 00:00:00

abstract：:Metabolic syndrome (MetS) is a complex, emerging epidemic which disrupts the metabolic homeostasis of several organs, including liver, heart, pancreas, and adipose tissue. While studies have been conducted in these research areas, the pathogenesis and mechanisms of MetS remain debatable. Lines of evidence show that ph...

journal_title：Cell death & disease

authors： Menikdiwela KR,Ramalingam L,Rasha F,Wang S,Dufour JM,Kalupahana NS,Sunahara KKS,Martins JO,Moustaid-Moussa N

更新日期：2020-02-03 00:00:00

abstract：:Only a few types of inflammasomes have been described in central nervous system cells. Among these, the absent in melanoma 2 (AIM2) inflammasome is primarily found in neurons, is highly specific and can be activated only by double-stranded DNA. Although it has been demonstrated that the AIM2 inflammasome is activated ...

journal_title：Cell death & disease

authors： Yuan B,Zhou XM,You ZQ,Xu WD,Fan JM,Chen SJ,Han YL,Wu Q,Zhang X

更新日期：2020-01-30 00:00:00

abstract：:Poly(ADP-ribose) polymerase 1 (PARP1) regulates gene transcription in addition to functioning as a DNA repair factor. Forkhead box O1 (FoxO1) is a transcription factor involved in extensive biological processes. Here, we report that PARP1 binds to two separate motifs on the FoxO1 promoter and represses its transcripti...

journal_title：Cell death & disease

authors： Tian YN,Chen HD,Tian CQ,Wang YQ,Miao ZH

更新日期：2020-01-28 00:00:00

abstract：:The original version of this article contained an error in the name of one of the co-authors (Kayvan Mohkam). This has been corrected in the PDF and HTML versions. ...

journal_title：Cell death & disease

authors： Roger E,Martel S,Bertrand-Chapel A,Depollier A,Chuvin N,Pommier RM,Yacoub K,Caligaris C,Cardot-Ruffino V,Chauvet V,Aires S,Mohkam K,Mabrut JY,Adham M,Fenouil T,Hervieu V,Broutier L,Castets M,Neuzillet C,Cassier PA,

更新日期：2020-01-23 00:00:00

abstract：:Autophagy plays an important role in the regulation of autoimmune and autoinflammatory responses of the immune cells. Defective autophagy process is associated with various autoimmune and inflammatory diseases. Moreover, in many of these diseases, the therapeutic use of normal immunoglobulin G or intravenous immunoglo...

journal_title：Cell death & disease

authors： Das M,Karnam A,Stephen-Victor E,Gilardin L,Bhatt B,Kumar Sharma V,Rambabu N,Patil V,Lecerf M,Käsermann F,Bruneval P,Narayanaswamy Balaji K,Benveniste O,Kaveri SV,Bayry J

更新日期：2020-01-23 00:00:00

abstract：:Numerous evidences have shown that circular RNAs (circRNAs) play a key role in regulating the pathogenesis of cancer. However, the mechanism of circRNAs in urothelial carcinoma of bladder (UCB) remains largely unclear. In this study, we found circFAM114A2 was significantly downregulated both in UCB tissue specimens an...

journal_title：Cell death & disease

authors： Liu T,Lu Q,Liu J,Xie S,Feng B,Zhu W,Liu M,Liu Y,Zhou X,Sun W,Zhang Y,Chen X,Fang F,Guo H,Yang R

更新日期：2020-01-22 00:00:00

abstract：:Circular RNAs (circRNAs) have been identified play a vital role in various different types of cancer via sponging miRNAs (microRNAs). However, their role in lung adenocarcinoma (LUAD) remains largely unclear. In this study, we systematically characterized the circRNA expression profiles in the LUAD cancer tissues and ...

journal_title：Cell death & disease

authors： Wang J,Zhao X,Wang Y,Ren F,Sun D,Yan Y,Kong X,Bu J,Liu M,Xu S

更新日期：2020-01-16 00:00:00

abstract：:Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly. Dry AMD is characterized by a progressive macular degeneration of the retinal pigment epithelium (RPE) and photoreceptors, and the RPE oxidative damage/dystrophy is at the core of the disease. Recent population/patients-based stud...

journal_title：Cell death & disease

authors： Ma H,Yang F,Ding XQ

更新日期：2020-01-13 00:00:00

abstract：:Psoriasis is an autoimmune skin disease, where chronic immune responses due to exaggerated cytokine signaling, abnormal differentiation, and evasion of keratinocytes apoptosis plays a crucial role in mediating abnormal keratinocytes hyperproliferation. From the therapeutic perspective, the molecules with strong anti-p...

journal_title：Cell death & disease

authors： Thatikonda S,Pooladanda V,Sigalapalli DK,Godugu C

更新日期：2020-01-10 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Cell death & disease

authors： Talty A,Deegan S,Ljujic M,Mnich K,Naicker SD,Quandt D,Zeng Q,Patterson JB,Gorman AM,Griffin MD,Samali A,Logue SE

更新日期：2020-01-06 00:00:00

abstract：:Radiation-induced lung injury (RILI) is one of the most common and fatal complications of thoracic radiotherapy, whereas no effective interventions are available. Andrographolide, an active component extracted from Andrographis paniculate, is prescribed as a treatment for upper respiratory tract infection. Here we rep...

journal_title：Cell death & disease

authors： Gao J,Peng S,Shan X,Deng G,Shen L,Sun J,Jiang C,Yang X,Chang Z,Sun X,Feng F,Kong L,Gu Y,Guo W,Xu Q,Sun Y

更新日期：2019-12-20 00:00:00

abstract：:A primary cilium is an antenna-like structure on the cell surface that plays a crucial role in sensory perception and signal transduction. Mitochondria, the 'powerhouse' of the cell, control cell survival, and death. The cellular ability to remove dysfunctional mitochondria through mitophagy is important for cell surv...

journal_title：Cell death & disease

authors： Bae JE,Kang GM,Min SH,Jo DS,Jung YK,Kim K,Kim MS,Cho DH

更新日期：2019-12-16 00:00:00

abstract：:Bone loss in postmenopausal osteoporosis is induced chiefly by an imbalance of bone-forming osteoblasts and bone-resorbing osteoclasts. Salubrinal is a synthetic compound that inhibits de-phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2α). Phosphorylation of eIF2α alleviates endoplasmic reticu...

journal_title：Cell death & disease

authors： Li J,Li X,Liu D,Hamamura K,Wan Q,Na S,Yokota H,Zhang P

更新日期：2019-12-04 00:00:00

abstract：:Excessive fibrogenic response in the liver disrupts normal hepatic anatomy and function heralding such end-stage liver diseases as hepatocellular carcinoma and cirrhosis. Sinusoidal endothelial cells contribute to myofibroblast activation and liver fibrosis by undergoing endothelial-mesenchymal transition (EndMT). The...

journal_title：Cell death & disease

authors： Li Z,Chen B,Dong W,Kong M,Fan Z,Yu L,Wu D,Lu J,Xu Y

更新日期：2019-11-27 00:00:00